Publications

If you have any specific research questions or open access requests please contact the lead author in the first instance.

2020

Doig CL, Zielinska AE, Fletcher RS, Oakey LA, Elhassan YS, Garten A, Cartwright D, Heising S, Alsheri A, Watson DG, Prehn C, Adamski J, Tennant DA, Lavery GG.Induction of the nicotinamide riboside kinase NAD⁺ salvage pathway in a model of sarcoplasmic reticulum dysfunction. Skeletal Muscle. 2020 Feb 19;10(1):5. PMID: 32075690

Dollerup OL, Chubanava S, Agerholm M, Søndergård SD, Altıntaş A, Møller AB, Høyer KF, Ringgaard S, Stødkilde-Jørgensen H, Lavery GG, Barrès R, Larsen S, Prats C, Jessen N, Treebak JT. Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin-resistant men. J Physiol. 2020 Feb;598(4):731-754. PMID: 31710095

Sayers SR, Beavil RL, Fine NHF, Huang GC, Choudhary P, Pacholarz KJ, Barran PE, Butterworth S, Mills CE, Cruickshank JK, Silvestre MP, Poppitt SD, McGill AT, Lavery GG, Hodson DJ, Caton PW. Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes. Diabetologia. 2020 Feb;63(2):313-323. PMID: 31732790

Fletcher A, Read ML, Thornton CEM, Larner DP, Poole VL, Brookes K, Nieto HR, Alshahrani M, Thompson RJ, Lavery GG, Landa I, Fagin JA, Campbell MJ, Boelaert K, Turnell AS, Smith VE, McCabe CJ. Targeting Novel Sodium Iodide Symporter Interactors ADP-Ribosylation Factor 4 and Valosin-Containing Protein Enhances Radioiodine Uptake. Cancer Res. 2020 Jan 1;80(1):102-115. PMID: 31672844

2019

Kľučková K, Thakker A, Vettore L, Escribano-Gonzalez C, Hindshaw RL, Tearle JLE, Goncalves J, Kaul B, Lavery GG, Favier J, Tennant DA. Succinate dehydrogenase deficiency in a chromaffin cell model retains metabolic fitness through the maintenance of mitochondrial NADH oxidoreductase function. FASEB J. 2020 Jan;34(1):303-315. PMID: 31914648

Fine NH, Doig CL, Elhassan YS, Vierra NC, Marchetti P, Bugliani M, Nano R, Piemonti L, Rutter GA, Jacobson DA, Lavery GG, Hodson DJ. Glucocorticoids Reprogram Beta Cell Signaling to Preserve Insulin Secretion. Diabetes. 2018 Feb;67(2):278-290.

Diguet N, Trammell SA, Tannous C, Deloux R, Piquereau J, Mougenot N, Decaux JF, Lavery GG, Zoll J, Garnier A, Li Z, Brenner C, Mericskay M. Nicotinamide riboside preserves cardiac function in a mouse model of dilated cardiomyopathy. Circulation. 2018 May 22;137(21):2256-2273

Doig CL, Fletcher RS, Morgan SA, McCabe EL, Larner DP, Tomlinson JW, Stewart PM, Philp A, Lavery GG. 11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice. Endocrinology. 2017 Jun 1;158(6):1964-1976.

Fletcher RS, Ratajczak J, Doig CL, Oakey LA, Callingham R, Da Silva Xavier G, Garten A, Elhassan YS, Redpath P, Migaud ME, Philp A, Brenner C, Canto C, Lavery GG. Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells. Mol Metab. 2017 May 29;6(8):819-832.

Zielinska AE, Fletcher RS, Sherlock M, Doig CL, Lavery GG. Cellular and genetic models of H6PDH and 11β-HSD1 function in skeletal muscle. Cell Biochem Funct. 2017 Jul;35(5):269-277

Hardy RS, Doig CL, Hussain Z, O’Leary M, Morgan SA, Pearson MJ, Naylor A, Jones SW, Filer A, Stewart PM, Buckley CD, Lavery GG, Cooper MS, Raza K. 11β-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation. J Pathol. 2016 Dec;240(4):472-483.

Zeng X, Jedrychowski MP, Chen Y, Serag S, Lavery GG, Gygi SP, Spiegelman BM. Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation. Genes Dev. 2016 Aug 15;30(16):1822-36.

Larner DP, Morgan SA, Gathercole LL, Doig CL, Guest P, Weston C, Hazeldine J, Tomlinson JW, Stewart PM and Lavery GG. Male 11β-HSD1 knockout mice fed trans-fats and fructose are not protected from metabolic syndrome or non-alcoholic fatty liver disease. Endocrinology. 2016 Jul 6:en20161357.

Morgan SA, Hassan-Smith Z, Doig CL, Sherlock M, Stewart PM, Lavery GG. Glucocorticoids and 11β-HSD1 are major regulators of intramyocellular protein metabolism. J Endocrinol. 2016 Jun;229(3):277-86.

Hassan-Smith ZK, Morgan SA, Sherlock M, Hughes B, Taylor AE, Lavery GG, Tomlinson JW, Stewart PM. Gender-Specific Differences in Skeletal Muscle 11β-HSD1 Expression Across Healthy Aging. J Clin Endocrinol Metab. 2015, Jul;100(7):2673-81.

Morgan SA, McCabe EL, Gathercole , Hassan-Smith ZK, Larner DP, Bujalska IJ, Stewart PM, Tomlinson JW*, Lavery GG*. 11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess. PNAS. 2014 Jun 17;111(24):E2482-91. *Joint senior Authors.

Doig CL, Bashir J, Zielinska AE, Cooper MS, Stewart PM, Lavery GG. TNFα mediated HSD11B1 binding of NF-κB p65 is associated with suppression of 11β-HSD1 in muscle. J Endocrinol. 2014, Feb 10;220(3):389-96.

Dowman JK, Hopkins LJ, Reynolds GM, Armstrong MJ, Lavery GG, Oprescu A, Hübscher SG, Newsome PN, Tomlinson JW. Loss of 5α-reductase type 1 Accelerates the Development of Hepatic Steatosis but Protects Against Hepatocellular Carcinoma in Male Mice. Endocrinology. 2013, Dec;154(12):4536-47.

Morgan SA, Gathercole LL, Simonet C, Hassan-Smith Z, Bujalska I, Guest P, Abrahams L, Smith D Stewart PM, Lavery GG and Tomlinson JW .Regulation of Lipid Metabolism by Glucocorticoids and 11β-HSD1 in Skeletal Muscle. Endocrinology. 2013, Jul;154(7):2374-84.

Tiganescu A, Tahrani A, Morgan SA, Otranto M, Desmoulière A, Abrahams L, Hassan-Smith Z, Walker EA, Rabbitt EH, Cooper MS, Amrein K, Stewart PM* and Lavery GG*. 11ß-hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects. J Clin Invest. 2013 Jul 1;123(7):3051-60. *Joint senior Authors.

Lavery GG, Rabbitt EH, Zielinska AE, Hughes B, Semjonous N, Guest P, Saqib K, M Sherlock, Gathercole LL, Morgan S, Walker EA, Stewart PM. Lack of Significant Metabolic Abnormalities in Mice With Liver-Specific Disruption of 11β-hydroxysteroid Dehydrogenase Type 1 . Endocrinology. 2012, Jul;153(7):3236-48.

Lawson AJ, Walker EA, Lavery GG, Bujalska IJ, Hughes BA, Arlt W, Stewart PM, Ride JP. Cortisone-reductase deficiency associated with heterozygous mutations in 11beta-hydroxysteroid dehydrogenase type 1. PNAS. 2011, Mar 8;108(10):4111-6.